This software uses nonlinear regression fits of dose responses to determine synergism by the Bliss independence and Loewe additivity analysis models.
We describe the development and use of the SynScreen software application, which allows for visual and mathematical determinations of compound concentrations that produce super-additive effects. Thus, the discovery of synergistic drug combinations would permit treatment with lower, tolerable dosages of each agent and restored sensitivity. Classical therapeutic regimens are subject to toxicity, low efficacy, and/or the development of drug resistance.
