Isaac dies if he has a single heart container and an Eternal heart then makes a deal costing more two or more hearts. What happens if isaac has an eternal heart? The top row is filled before the bottom row. The order in which hearts are placed is, from left to right, Red Hearts (and empty Red Heart containers), Rotten Hearts, then Eternal Hearts, then Soul Hearts, Black Hearts, and Bone Hearts (depending on the order in which they were picked up), then Broken Hearts. Frequently Asked Questions How are hearts placed in the binding of isaac?